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Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Jiao X, Wang M, Zhang Z, Li Z, Ni D, Ashton AW, Tang HY, Speicher DW, Pestell RG.Breast Cancer Res. 2021 Jan 23;23(1):11. doi: 10.1186/s13058-021-01391-1.
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An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5.Lah Turnšek T, Jiao X, Novak M, Jammula S, Cicero G, Ashton AW, Joyce D, Pestell RG.Int J Mol Sci. 2021 Apr 24;22(9):4464.
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CCR5-Mediated Signaling Is Involved in Invasion of Glioblastoma Cells in Its Microenvironment.Novak M, Koprivnikar Krajnc M, Hrastar B, Breznik B, Majc B, Mlinar M, Rotter A, Porčnik A, Mlakar J, Stare K, Pestell RG, Lah Turnšek T.Int J Mol Sci. 2020 Jun 12;21(12):4199. doi: 10.3390/ijms21124199
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The G protein coupled receptor CCR5 in cancer. Upadhyaya C, Jiao X, Ashton A, Patel K, Kossenkov AV, Pestell RG.Adv Cancer Res. 2020;145:29-47. doi: 10.1016/bs.acr.2019.11.001. Epub 2020 Jan 10.PMID: 32089164
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Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme. Kranjc MK, Novak M, Pestell RG, Lah TT.Radiol Oncol. 2019 Nov 20;53(4):397-406. doi: 10.2478/raon-2019-0057.
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Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology. Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, Pestell RG.Cancer Res. 2019 Oct 1;79(19):4801-4807. doi: 10.1158/0008-5472.CAN-19-1167. Epub 2019 Jul 10.
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CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.Jiao X, Velasco-Velázquez MA, Wang M, Li Z, Rui H, Peck AR, Korkola JE, Chen X, Xu S, DuHadaway JB, Guerrero-Rodriguez S, Addya S, Sicoli D, Mu Z, Zhang G, Stucky A, Zhang X, Cristofanilli M, Fatatis A, Gray JW, Zhong JF, Prendergast GC, Pestell RG.Cancer Res. 2018 Apr 1;78(7):1657-1671. doi: 10.1158/0008-5472.CAN-17-0915. Epub 2018 Jan 22
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CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Andò S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP, Pestell RG.Cancer Res. 2014 Dec 1;74(23):7103-14. doi: 10.1158/0008-5472.CAN-14-0612
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The potential to target CCL5/CCR5 in breast cancer. Velasco-Velázquez M, Xolalpa W, Pestell RG.Expert Opin Ther Targets. 2014 Nov;18(11):1265-75. doi: 10.1517/14728222.2014.949238. Epub 2014 Sep 26.
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CCR5 antagonist blocks metastasis of basal breast cancer cells. Velasco-Velázquez M, Jiao X, De La Fuente M, Pestell TG, Ertel A, Lisanti MP, Pestell RG.Cancer Res. 2012 Aug 1;72(15):3839-50. doi: 10.1158/0008-5472.CAN-11-3917. Epub 2012 May 25
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Cancer stem cells (CSC): genetic drivers and therapeutic targeting via CCR5R Pestell FEBS OPEN BIO 11, 57-58
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The G protein coupled receptor CCR5 in cancer C Upadhyaya, X Jiao, A Ashton, K Patel, AV Kossenkov, RG Pestell
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Use of modulators of ccr5 in the treatment of cancer and cancer metastasisRG Pestell US Patent App. 16/363,981
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Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-OncologyTargeting CCR5 for Cancer X Jiao, O Nawab, T Patel, AV Kossenkov, N Halama, D Jaeger, ... Cancer research 79 (19), 4801-4807
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Anti-ccr5 agents and methods of treatment that block cancer metastasis or enhance cell death induced by dna damaging chemotherapyS Kelly, RG Pestell US Patent App. 17/598,650
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Cancers expressing ccr5 and methods of treatment of sameR Pestell, M Cristofanilli, X Jiao US Patent App. 15/738,020
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Use Of Modulators Of CCR5 In The Treatment Of Cancer And Cancer Metastasis RG Pestell US Patent App. 15/275,050
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Use of modulators of CCR5 in the treatment of cancer and cancer metastasis RG Pestell US Patent 9,453,836
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Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth C Guido, D Whitaker-Menezes, Z Lin, RG Pestell, A Howell, TA Zimmers, ... Oncotarget 3 (8), 798
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Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm MP Lisanti, F Sotgia, RG Pestell US Patent App. 13/202,312
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Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drugI Mercier, J Camacho, K Titchen, DM Gonzales, K Quann, KG Bryant, ... The American journal of pathology 181 (1), 278-293
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Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cellsAF Salem, D Whitaker-Menezes, Z Lin, UE Martinez-Outschoorn, ... Cell cycle 11 (13), 2545-2559
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CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growthC Capparelli, D Whitaker-Menezes, C Guido, R Balliet, TG Pestell, ... Cell Cycle 11 (12), 2272-2284
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Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone productionC Capparelli, C Guido, D Whitaker-Menezes, G Bonuccelli, R Balliet, ... Cell cycle 11 (12), 2285-2302
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Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic GlycolysisS Pavlides, I Vera, R Gandara, S Sneddon, RG Pestell, I Mercier, ... Antioxidants & redox signaling 16 (11), 1264-1284
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Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial MigrationCaveolin-1 …F Capozza, C Trimmer, R Castello-Cros, S Katiyar, D Whitaker-Menezes, ...
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10 Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the NeoplasmMP Lisanti, F Sotgia, RG Pestell US Patent App. 14/965,585
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Caveolin-1 regulates the anti-atherogenic properties of macrophages S Pavlides, JL Gutierrez-Pajares, S Katiyar, JF Jasmin, I Mercier, ... Cell and tissue research 358 (3), 821-831
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Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4UE Martinez-Outschoorn, JM Curry, YH Ko, Z Lin, M Tuluc, D Cognetti, ...Cell Cycle 12 (16), 2580-2597
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Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome? UE Martinez-Outschoorn, D Whitaker-Menezes, M Valsecchi, ... Seminars in Oncology 40 (4), 403-418
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Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide K Quann, DM Gonzales, I Mercier, C Wang, F Sotgia, RG Pestell, ...Cell Cycle 12 (10), 1510-1520
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Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activationC Trimmer, G Bonuccelli, S Katiyar, F Sotgia, RG Pestell, MP Lisanti, ...The American journal of pathology 182 (3), 992-1004
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CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts,“fueling” tumor growth via paracrine interactions, without an increase in neo …C Capparelli, B Chiavarina, D Whitaker-Menezes, TG Pestell, RG Pestell, ... Cell cycle 11 (19), 3599-3610
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Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growthV Carito, G Bonuccelli, UE Martinez-Outschoorn, D Whitaker-Menezes, ... Cell Cycle 11 (18), 3403-3414
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Metabolic reprogramming and two-compartment tumor metabolism: opposing role (s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cellsB Chiavarina, UE Martinez-Outschoorn, D Whitaker-Menezes, A Howell, ... Cell cycle 11 (17), 3280-3289
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Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate productionC Guido, D Whitaker-Menezes, C Capparelli, R Balliet, Z Lin, RG Pestell, ... Cell cycle 11 (16), 3019-3035
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New metastatic murine prostate cancer cell lines and preclinical model of human prostate cancer.X Ju, RG Pestell. Cancer Research 73 (8_Supplement), 320-320
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Novel Oncogene–Induced Metastatic Prostate Cancer Cell Lines Define Human Prostate Cancer Progression SignaturesNovel Cell Lines and Prostate Cancer ProgressionX Ju, A Ertel, MC Casimiro, Z Yu, H Meng, PA McCue, R Walters, ... Cancer research 73 (2), 978-989
