Publications

CCR5 Peer-Reviewed Publications

1. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Jiao X, Wang M, Zhang Z, Li Z, Ni D, Ashton AW, Tang HY, Speicher DW, Pestell RG.Breast Cancer Res. 2021 Jan 23;23(1):11. doi: 10.1186/s13058-021-01391-1.

2. An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5.Lah Turnšek T, Jiao X, Novak M, Jammula S, Cicero G, Ashton AW, Joyce D, Pestell RG.Int J Mol Sci. 2021 Apr 24;22(9):4464.

3. CCR5-Mediated Signaling Is Involved in Invasion of Glioblastoma Cells in Its Microenvironment.Novak M, Koprivnikar Krajnc M, Hrastar B, Breznik B, Majc B, Mlinar M, Rotter A, Porčnik A, Mlakar J, Stare K, Pestell RG, Lah Turnšek T.Int J Mol Sci. 2020 Jun 12;21(12):4199. doi: 10.3390/ijms21124199

4. The G protein coupled receptor CCR5 in cancer. Upadhyaya C, Jiao X, Ashton A, Patel K, Kossenkov AV, Pestell RG.Adv Cancer Res. 2020;145:29-47. doi: 10.1016/bs.acr.2019.11.001. Epub 2020 Jan 10.PMID: 32089164

5. Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme. Kranjc MK, Novak M, Pestell RG, Lah TT.Radiol Oncol. 2019 Nov 20;53(4):397-406. doi: 10.2478/raon-2019-0057.

6. Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology. Jiao X, Nawab O, Patel T, Kossenkov AV, Halama N, Jaeger D, Pestell RG.Cancer Res. 2019 Oct 1;79(19):4801-4807. doi: 10.1158/0008-5472.CAN-19-1167. Epub 2019 Jul 10.

7. CCR5 Governs DNA Damage Repair and Breast Cancer Stem Cell Expansion.Jiao X, Velasco-Velázquez MA, Wang M, Li Z, Rui H, Peck AR, Korkola JE, Chen X, Xu S, DuHadaway JB, Guerrero-Rodriguez S, Addya S, Sicoli D, Mu Z, Zhang G, Stucky A, Zhang X, Cristofanilli M, Fatatis A, Gray JW, Zhong JF, Prendergast GC, Pestell RG.Cancer Res. 2018 Apr 1;78(7):1657-1671. doi: 10.1158/0008-5472.CAN-17-0915. Epub 2018 Jan 22

8. CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines.Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Andò S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP, Pestell RG.Cancer Res. 2014 Dec 1;74(23):7103-14. doi: 10.1158/0008-5472.CAN-14-0612

9. The potential to target CCL5/CCR5 in breast cancer. Velasco-Velázquez M, Xolalpa W, Pestell RG.Expert Opin Ther Targets. 2014 Nov;18(11):1265-75. doi: 10.1517/14728222.2014.949238. Epub 2014 Sep 26.

10. CCR5 antagonist blocks metastasis of basal breast cancer cells. Velasco-Velázquez M, Jiao X, De La Fuente M, Pestell TG, Ertel A, Lisanti MP, Pestell RG.Cancer Res. 2012 Aug 1;72(15):3839-50. doi: 10.1158/0008-5472.CAN-11-3917. Epub 2012 May 25

11. Cancer stem cells (CSC): genetic drivers and therapeutic targeting via CCR5R Pestell FEBS OPEN BIO 11, 57-58

12. The G protein coupled receptor CCR5 in cancer C Upadhyaya, X Jiao, A Ashton, K Patel, AV Kossenkov, RG Pestell

13. Use of modulators of ccr5 in the treatment of cancer and cancer metastasisRG Pestell US Patent App. 16/363,981

14. Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-OncologyTargeting CCR5 for Cancer X Jiao, O Nawab, T Patel, AV Kossenkov, N Halama, D Jaeger, ... Cancer research 79 (19), 4801-4807

15. Anti-ccr5 agents and methods of treatment that block cancer metastasis or enhance cell death induced by dna damaging chemotherapyS Kelly, RG Pestell US Patent App. 17/598,650

16. Cancers expressing ccr5 and methods of treatment of sameR Pestell, M Cristofanilli, X Jiao US Patent App. 15/738,020

17. Use Of Modulators Of CCR5 In The Treatment Of Cancer And Cancer Metastasis RG Pestell US Patent App. 15/275,050

18. Use of modulators of CCR5 in the treatment of cancer and cancer metastasis RG Pestell US Patent 9,453,836

CAV1 Peer-Reviewed Publications

19. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth C Guido, D Whitaker-Menezes, Z Lin, RG Pestell, A Howell, TA Zimmers, ... Oncotarget 3 (8), 798

20. Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm MP Lisanti, F Sotgia, RG Pestell US Patent App. 13/202,312

21. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drugI Mercier, J Camacho, K Titchen, DM Gonzales, K Quann, KG Bryant, ... The American journal of pathology 181 (1), 278-293

22. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cellsAF Salem, D Whitaker-Menezes, Z Lin, UE Martinez-Outschoorn, ... Cell cycle 11 (13), 2545-2559

23. CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growthC Capparelli, D Whitaker-Menezes, C Guido, R Balliet, TG Pestell, ... Cell Cycle 11 (12), 2272-2284

24. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone productionC Capparelli, C Guido, D Whitaker-Menezes, G Bonuccelli, R Balliet, ... Cell cycle 11 (12), 2285-2302

25. Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic GlycolysisS Pavlides, I Vera, R Gandara, S Sneddon, RG Pestell, I Mercier, ... Antioxidants & redox signaling 16 (11), 1264-1284

26. Genetic Ablation of Cav1 Differentially Affects Melanoma Tumor Growth and Metastasis in Mice: Role of Cav1 in Shh Heterotypic Signaling and Transendothelial MigrationCaveolin-1 …F Capozza, C Trimmer, R Castello-Cros, S Katiyar, D Whitaker-Menezes, ...

27. 10 Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the NeoplasmMP Lisanti, F Sotgia, RG Pestell US Patent App. 14/965,585

28. Caveolin-1 regulates the anti-atherogenic properties of macrophages S Pavlides, JL Gutierrez-Pajares, S Katiyar, JF Jasmin, I Mercier, ... Cell and tissue research 358 (3), 821-831

29. Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4UE Martinez-Outschoorn, JM Curry, YH Ko, Z Lin, M Tuluc, D Cognetti, ...Cell Cycle 12 (16), 2580-2597

30. Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome?UE Martinez-Outschoorn, D Whitaker-Menezes, M Valsecchi, ... Seminars in Oncology 40 (4), 403-418

31. Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide K Quann, DM Gonzales, I Mercier, C Wang, F Sotgia, RG Pestell, ...Cell Cycle 12 (10), 1510-1520

32. Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activationC Trimmer, G Bonuccelli, S Katiyar, F Sotgia, RG Pestell, MP Lisanti, ...The American journal of pathology 182 (3), 992-1004

33. CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts,“fueling” tumor growth via paracrine interactions, without an increase in neo …C Capparelli, B Chiavarina, D Whitaker-Menezes, TG Pestell, RG Pestell, ... Cell cycle 11 (19), 3599-3610

34. Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growthV Carito, G Bonuccelli, UE Martinez-Outschoorn, D Whitaker-Menezes, ... Cell Cycle 11 (18), 3403-3414

35. Metabolic reprogramming and two-compartment tumor metabolism: opposing role (s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cellsB Chiavarina, UE Martinez-Outschoorn, D Whitaker-Menezes, A Howell, ... Cell cycle 11 (17), 3280-3289

36. Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate productionC Guido, D Whitaker-Menezes, C Capparelli, R Balliet, Z Lin, RG Pestell, ... Cell cycle 11 (16), 3019-3035

Gene signature Peer-Reviewed Publications

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